Regulation of the Human Platelet-derived Growth Factor B-chain Gene
Hiroshima Journal of Medical Sciences Volume 42 Issue 4
Page 137-142
published_at 1993-12
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| File | |
| Title ( eng ) |
Regulation of the Human Platelet-derived Growth Factor B-chain Gene
|
| Creator |
Takimoto Yasuo
Kuramoto Atsushi
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 42 |
| Issue | 4 |
| Start Page | 137 |
| End Page | 142 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
Human platelet-derived growth factor (PDGF) B chain is a cellular homologue of v-sis, closely involved in cell growth and oncogenicity. Analysis in this study showed the importance of not only the region near the TATAA box but also the fragment －355 bases or more upstream in the expression of the PDGF-B chain gene. However, tissue specificity was not clear in the 5' upstream region alone, and regulation by gene methylation or by elements other than in the 5' region seemed to be necessary. In A172 cells, the half-life of mRNA was much shorter in the PDGF-B chain (<2 hours) than in the PDGF-A chain (7 hours). Regulation of the PDGF-B chain gene may markedly differ from that of the PDGF-A chain gene not only at the transcriptional level but also at the post-transcriptional level.
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| Keywords |
PDGF-B chain gene
Transcription
Half life
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1993-12 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
|
