Adjuvant Chemotherapy for Patients with Soft Tissue Sarcoma

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Title ( eng )
Adjuvant Chemotherapy for Patients with Soft Tissue Sarcoma
Creator
Ozaki Toshifumi
Sugihara Shinsuke
Hamada Masanori
Nakagawa Yukou
Inoue Hajime
Source Title
Hiroshima Journal of Medical Sciences
Volume 42
Issue 3
Start Page 109
End Page 115
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
Forty patients with soft tissue sarcoma (Enneking's stage I and II) were treated in our department between 1965 and 1992. We administered VACA regimen (composed of vincristine, actinomycin-D, cyclophosphamide, and doxorubicin) to 14 of 40 patients. Among 40 patients, the 5-year survival rate was 56% in 14 patients with chemotherapy and 39% in 26 without chemotherapy (p<0.02). In 32 patients of Stage II, the 5-year survival rate was 40% in 11 patients with chemotherapy and 31 % without chemotherapy (p<0.05). The improvement of the survival rate was due to delay in the development of lung metastases (chemotherapy group: 21.2 months after first visit, non-chemotherapy group: 9.4 months) and prolongation of the survival period after metastases (chemotherapy group: 26 months, non-chemotherapy group: 7.4 months).
Keywords
Soft tissue sarcoma
Chemotherapy
Survival
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University Medical Press
Date of Issued 1993-09
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[NCID] AA00664312