Microsatellite Instability in Breast Cancers with Special Reference to Patients' Age and Bilaterality
Hiroshima Journal of Medical Sciences Volume 47 Issue 3
Page 89-97
published_at 1998-09
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| File | |
| Title ( eng ) |
Microsatellite Instability in Breast Cancers with Special Reference to Patients' Age and Bilaterality
|
| Creator |
Fujii Satoshi
Kaneko Mayumi
Inai Kouki
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 47 |
| Issue | 3 |
| Start Page | 89 |
| End Page | 97 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
We examined breast cancers from 67 female patients to ascertain the possible correlation between RER or LOH status, age and bilaterality using eight microsatellite markers on chromosomes 2p, 3p, 16q, 17p and 17q. The frequencies of RER in young patients (25-35 years old), patients with double primary disease (43-77 years old) and patients with contralateral metastases (46-72 years old) were 35%, 63%, and 80%, respectively, while that in elderly patients (60-81 years old) was 0%. In contrast, there were no statistically significant differences in the frequency of LOH between these groups. Our results suggest that RER might play an important role in the occurrence of breast cancer at a younger age and in bilateral breast cancer.
|
| Keywords |
Replication error (RER)
Loss of heterozygosity (LOH)
Young
Bilateral breast cancer
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1998-09 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
|
