Dl-α-tocopherol enhances the herbicide 1,1'-dimetyl-4,4'-bipyridium dichloride (paraquat, PQ) genotoxicity in cultured anuran leukocytes
Hereditas 148 巻 4-5 号
118-124 頁
2011-11 発行
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ファイル情報(添付) | |
タイトル ( eng ) |
Dl-α-tocopherol enhances the herbicide 1,1'-dimetyl-4,4'-bipyridium dichloride (paraquat, PQ) genotoxicity in cultured anuran leukocytes
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作成者 | |
収録物名 |
Hereditas
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巻 | 148 |
号 | 4-5 |
開始ページ | 118 |
終了ページ | 124 |
抄録 |
This cytogenetic and pharmacological study attempts to clarify genotoxicity-enhancement-effect of dl-α-tocopherol (one form of vitamin E) in combination with the herbicide 1,1'-dimetyl-4,4'-bipyridium dichloride (paraquat, PQ) on cultured anuran leukocytes using the superoxide dismutase-mimic Mn(III)tetrakis(1-methyl-4-pyridyl)porphyrin (Mn(III)TMpyP), the hydrogen peroxide-scavenger catalase and the electron donor nicotinamide adenine dinucleotido phosphate (NADPH). PQ only was found to induce structural chromosomal damage in cultured anuran leukocytes in a dose-dependent manner. PQ plus NADPH, which served as positive control, enhanced the genotoxic effect of PQ. Dl-α-tocopherol only did not induce any structural chromosomal damage in the leukocytes. PQ plus dl-α-tocopherol, however, enhanced the genotoxic effect of PQ. PQ plus Mn(III)TMpyP, PQ plus catalase and PQ plus Mn(III)TMpyP plus catalse suppressed the genotoxic effect of PQ. Furthermore, PQ plus dl-α-tocopherol-enhanced chromosomal damage was also inhibited by Mn(III)TMpyP plus catalase. These results suggest that dl-α-tocopherol in combination with PQ functions as an electron donor to PQ.
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NDC分類 |
生物科学・一般生物学 [ 460 ]
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言語 |
英語
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資源タイプ | 学術雑誌論文 |
出版者 |
Mendelian Society of Lund
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発行日 | 2011-11 |
権利情報 |
(c) 2011 The Authors
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出版タイプ | Version of Record(出版社版。早期公開を含む) |
アクセス権 | オープンアクセス |
収録物識別子 |
[ISSN] 0018-0661
[DOI] 10.1111/j.1601-5223.2011.02226.x
[NCID] AA00663626
[DOI] http://dx.doi.org/10.1111/j.1601-5223.2011.02226.x
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