Epileptic Spasms After Stem Cell Transplantation for Chronic Epstein-Barr Virus Infection

Ishikawa Nobutsune

Tajima Go

Kobayashi Masao

Pediatrci Neurokogy

Stem cell transplantation has been performed for various diseases, contributing to a markedly improved prognosis in some cases. However, several complications, including posterior reversible encephalopathy syndrome, have been evident. Although posterior reversible encephalopathy syndrome was originally defined as a reversible disease, it has become clear that it is not reversible in all patients. Epstein-Barr virus causes a wide spectrum of neurologic disorders, including epilepsy. To our knowledge, Epstein-Barr virus was not previously reported to cause epileptic spasms. We describe a girl with epileptic spasms after posterior reversible encephalopathy syndrome associated with stem cell transplantation for chronic Epstein-Barr virus infection. Although direct correlation was not clarified, this is a rare case that may contribute to our understanding of the neurologic complications of stem cell transplantation for chronic Epstein-Barr virus infection.

Epileptic spasms

Intractable epilepsy

Stem cell transplantation

Epstein-Barr virus infection

Posterior reversible encephalopathy syndrome

Medical sciences [ 490 ]

eng

Elsevier Science Ing

Copyright (c) 2009 Elsevier Science Inc.

[ISSN] 0887-8994

[DOI] 10.1016/j.pediatrneurol.2008.11.005

[NCID] AA10472238

[DOI] http://dx.doi.org/10.1016/j.pediatrneurol.2008.11.005