Relationship between Intratumoral Hemorrhage and Overexpression of Vascular Endothelial Growth Factor (VEGF) in Pituitary Adenoma

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タイトル ( eng )
Relationship between Intratumoral Hemorrhage and Overexpression of Vascular Endothelial Growth Factor (VEGF) in Pituitary Adenoma
作成者
Arita Kazunori
Eguchi Kuniki
Yoshioka Hiroyuki
Kanou Yukari
収録物名
Hiroshima Journal of Medical Sciences
53
2
開始ページ 23
終了ページ 27
収録物識別子
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
抄録
The authors investigated the relationship between hemorrhage and the expression of vascular endothelial growth factor (VEGF) in pituitary adenomas. The subjects were 39 patients with pituitary adenomas. Surgically obtained tumor tissue was immunohistochemically stained using antibodies against VEGF, CD-34, Ki-67, and anterior pituitary hormones. The expression of VEGF was graded as 0, 1+, and 2+. The relationship between intratumoral hemorrhage and factors such as tumor size, Ki-67 labeling indices, number of CD-34 positive vessels, and VEGF expression was examined by multivariate analysis. High-grade VEGF expression was the sole independent factor correlated with intratumoral hemorrhage. The number of CD-34 positive vessels had no effect on the incidence of hemorrhage in patients with pituitary adenomas. In conclusion, a positive relationship between VEGF expression and hemorrhage in pituitary adenoma was observed. The patho-mechanical significance of this correlation is under investigation.
著者キーワード
Vascular endothelial growth factor
Pituitary adenoma
Hemorrhage
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 紀要論文
出版者
Hiroshima University Medical Press
国立情報学研究所
発行日 2004-06
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0018-2052
[NCID] AA00664312