High frequency of open-angle glaucoma in Japanese patients with Alzheimer's disease

Journal of the Neurological Sciences 246 巻 1-2 号 79-83 頁 2006-07-15 発行
アクセス数 : 1101
ダウンロード数 : 219

今月のアクセス数 : 1
今月のダウンロード数 : 7
ファイル情報(添付)
JNeuroSci_246_79.pdf 233 KB 種類 : 全文
タイトル ( eng )
High frequency of open-angle glaucoma in Japanese patients with Alzheimer's disease
作成者
Tamura Hiroki
Kanamoto Takashi
Kato Tomoko
Sasaki Ken
Izumi Yuishin
Mishima Hiromu K.
収録物名
Journal of the Neurological Sciences
246
1-2
開始ページ 79
終了ページ 83
抄録
The clinical and genetic relationships between Alzheimer's disease (AD) and glaucoma remain obscure. The aim of this study was to determine the prevalence of open-angle glaucoma (OAG) in patients with AD and whether the apolipoprotein E (APOE) 4 allele is associated with AD, with or without OAG, in Japanese. The groups consisted of 172 patients with the diagnostic criteria of AD and 176 age-matched controls. Ophthalmic examinations were conducted, and genomic analysis was performed by PCR and digestion of products with an enzyme. OAG was found in 41 (23.8%) of the AD patients, which was a significantly (p=0.0002) higher prevalence than that in the controls (9.9%). Furthermore, there was no significant difference between intraocular pressures (IOPs) in AD patients with OAG and without OAG. The percentage of AD patients who carried an APOE ε4 allele (29.5%) was significantly (p=0.0007) higher than that of the controls (9.1%). However, the percentage of AD patients with OAG who carried an APOE ε4 allele (35.7%) was not significantly different than that of AD patients without OAG (27.7%, p=0.42). In summary, the prevalence of OAG is high in Japanese patients with AD, suggesting that common factors other than APOE may contribute to the two diseases.
著者キーワード
Alzheimer's disease (AD)
Open-angle glaucoma (OAG)
Apolipoprotein E (APOE)
Intraocular pressure (IOP)
Japanese
Prevalence
Polymorphism
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 学術雑誌論文
出版者
Elsevier
発行日 2006-07-15
権利情報
Copyright (c) 2006 Elsevier Ltd.
出版タイプ Author’s Original(十分な品質であるとして、著者から正式な査読に提出される版)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0022-510X
[DOI] 10.1016/j.jns.2006.02.009
[PMID] 16564058
[NCID] AA00703265
[DOI] http://dx.doi.org/10.1016/j.jns.2006.02.009