Chronic inhibition of the norepinephrine transporter in the brain participates in the seizure sensitization to cocaine and local anesthetics
Brain research 964 巻 1 号
83-90 頁
2003-02-21 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Chronic inhibition of the norepinephrine transporter in the brain participates in the seizure sensitization to cocaine and local anesthetics
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| 作成者 |
Arai Shigeaki
Kitayama Shigeo
Kumagai Kei
Kumagai Michiko
Dohi Toshihiro
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| 収録物名 |
Brain research
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| 巻 | 964 |
| 号 | 1 |
| 開始ページ | 83 |
| 終了ページ | 90 |
| 抄録 |
Involvement of chronic inhibition of monoamine transporters (MAT) in the brain concerning the sensitization of cocaine- and local anesthetic-induced seizures was studied in mice. Repeated administration of subconvulsive doses of meprylcaine as well as cocaine, both of which inhibit MAT, but not lidocaine, which does not inhibit MAT, increased seizure activity and produced sensitization to other local anesthetics. Effects of 5 daily treatments of monoamine transporter inhibitors on lidocaine-induced convulsions were examined 2 or 3 days after the last dose of the inhibitors. The daily treatments of GBR 12935, a specific inhibitor of dopamine uptake, significantly increased the incidence and the intensity of lidocaine-induced convulsions at 20 mg/kg and decreased the threshold of the convulsions. The daily treatments of desipramine and maprotiline, selective norepinephrine uptake inhibitors, markedly increased the incidence and intensity of lidocaine-induced convulsions, and decreased the threshold with dose-dependent manner between 5 and 20 mg/kg. The daily treatments of citaloplam, a selective serotonin uptake inhibitor, 10 and 20 mg/kg, produced no significant increase in the incidence or intensity of lidocaine-induced convulsions but decreased the threshold of the convulsions. These results suggest that the chronic intermittent inhibition of monoamine uptake increases susceptibility to cocaine- and local anesthetic-induced seizures, and a norepinephrine transporter is an integral component of this sensitization.
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| 著者キーワード |
Inhibition of monoamine transporters
Seizure
Kindling
Local anesthetics
Cocaine
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
Elsevier Science B.V.
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| 発行日 | 2003-02-21 |
| 権利情報 |
Copyright (c) 2002 Elsevier Science B.V.
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| 出版タイプ | Author’s Original（十分な品質であるとして、著者から正式な査読に提出される版） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[DOI] 10.1016/S0006-8993(02)04068-4
[PMID] 12573515
[DOI] http://dx.doi.org/10.1016/S0006-8993(02)04068-4
～の異版である
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